Evidence for multiple structural genes for the γ chain of human fetal hemoglobin

A sequence with a specific residue at each position was proposed for the γ chain of human fetal hemoglobin by Schroeder et al. (1) after a study in which hemoglobin from a number of individual infants was used. We have now examined in part the fetal hemoglobin components of 17 additional infants and have observed that position 136 of the γ chain may be occupied not only by a glycyl residue, as previously reported, but also by an alanyl residue

A review of treatment programs for offenders with co-occurring addictive and mental disorders: support for booster interventions

Background: Treatment interventions are essential in supporting psychosocial skills, health promotion and successful reintegration to community living for incarcerated persons. Booster interventions are presumed to be important methods for maintaining the effects of treatment effects for persons with addiction and mental disorders, but there has been remarkably little empirical attention to this assumption. Objectives: This review aims are: (1) to describe existing literature on treatment programs for offenders with addiction and mental disorders in the reentry process, and, (2) to add to the literature on this topic by evaluating the impact of booster interventions upon maintenance of treatment effects and outcomes - specifically, a reduction in symptoms, reduced substance abuse, medication adherence, coping, independent functioning and decreased depressive symptoms. Methods: Electronic databases were searched for systematic reviews from January 2004 through January 2014 to include: CINAHL PubMed, and PsycINFO using selected keywords. Inclusion criteria were adult offenders, a treatment intervention in prison, jail, or forensic psychiatric hospital with a reentry focus for offenders with addiction and mental disorder. The AMSTAR was utilized to assess quality of the reviews. Results: Three systematic reviews were identified to examine treatment interventions for offenders with addiction and mental disorders. Little empirical evidence is available to demonstrate the contribution of booster interventions to overall treatment effects among justice-involved persons. Conclusion: Although evidence is not available, clinically it seems reasonable to expect booster interventions for offenders to reinforce treatment gains, strengthen self-care skills, and manage symptoms. Implications: Research designed specifically to study booster interventions are needed. Keywords: offender reentry, correctional institutions, offenders, treatment programs, mental illness, booster program

End Tidal Carbon Dioxide Monitoring (Capnography) in the Cardiac Intensive Care Unit

Background: Carbon dioxide levels can be monitored throughout the respiratory cycle via capnography. In this way, capnography allows healthcare professionals to follow several respiratory factors in real-time, including respiratory depression, apnea, and hypercapnia. Postoperative patients are subjected to significant harm while receiving sedating medications without appropriate monitoring and intervention. Earlier detection of alterations to ventilation status will better enable providers to more accurately dose medications during procedures, especially in high-risk patient populations. Methods: Patient selection included post-operative patients in the intensive care unit that were receiving sedation/analgesia, high dose or high frequency opioids, epidural or intrathecal pain management, patients that are difficult to arouse, patients with a history of respiratory disease, and patients undergoing resuscitative efforts and/or endotracheal intubation. Patients were monitored with capnography to assess respiratory distress indicators and capnography waveforms. Results: The high-risk target populations above should receive continuous pulse oximetry by telemetry. If supplemental oxygen is used, add continuous EtCO2 monitoring. Pulse oximetry may suggest adequate oxygenation in patients who are actively experiencing respiratory depression when supplemental oxygen is used. Capnography indicators of respiratory depression include no waveform for any period, change in EtCO2 of 20% above baseline, hypoventilation, shallow breathing hypoventilation, airway obstruction, apnea, or rebreathing EtCO2. Definitions and descriptions of waveforms for each capnography indicator is described in Table 2. Conclusions: Capnography is an essential monitoring device for post-operative patients in the intensive care unit. Monitoring carbon dioxide levels will help decrease the morbidity and mortality in high-risk surgical patients who experience postoperative pulmonary complications

Surprisingly Little O VI Emission Arises in the Local Bubble

This paper reports the first study of the O VI resonance line emission (1032, 1038 Angstroms) originating in the Local Bubble (or Local Hot Bubble) surrounding the solar neighborhood. In spite of the fact that O VI absorption within the Local Bubble has been observed, no resonance line emission was detected during our 230 ksec Far Ultraviolet Spectroscopic Explorer observation toward a ``shadowing'' filament in the southern Galactic hemisphere. As a result, tight 2 sigma upper limits are set on the intensities in the 1032 and 1038 Angstrom emission lines: 500 and 530 photons cm^{-2} s^{-1} sr^{-1}, respectively. These values place strict constraints on models and simulations. They suggest that the O VI-bearing plasma and the X-ray emissive plasma reside in distinct regions of the Local Bubble and are not mixed in a single plasma, whether in equilibrium with T ~ 10^6 K or highly overionized with T ~ 4 to 6 x 10^4 K. If the line of sight intersects multiple cool clouds within the Local Bubble, then the results also suggest that hot/cool transition zones differ from those in current simulations. With these intensity upper limits, we establish limits on the electron density, thermal pressure, pathlength, and cooling timescale of the O VI-bearing plasma in the Local Bubble. Furthermore, the intensity of O VI resonance line doublet photons originating in the Galactic thick disk and halo is determined (3500 to 4300 photons cm^{-2} s^{-1} sr^{-1}), and the electron density, thermal pressure, pathlength, and cooling timescale of its O VI-bearing plasma are calculated. The pressure in the Galactic halo's O VI-bearing plasma (3100 to 3800 K cm^{-3}) agrees with model predictions for the total pressure in the thick disk/lower halo. We also report the results of searches for other emission lines.Comment: accepted by ApJ, scheduled for May 2003, replacement astro-ph submission corrects typos and grammatical errors in original versio

One-dimensional spin-liquid without magnon excitations

It is shown that a sufficiently strong four-spin interaction in the spin-1/2 spin ladder can cause dimerization. Such interaction can be generated either by phonons or (in the doped state) by the conventional Coulomb repulsion between the holes. The dimerized phases are thermodynamically undistinguishable from the Haldane phase, but have dramatically different correlation functions: the dynamical magnetic susceptibility, instead of displaying a sharp single magnon peak near $q = \pi$, shows only a two-particle threshold separated from the ground state by a gap.Comment: 9 pages, LaTex, to be published in Phys. Rev. Lett., vol. 78, May 199

FUSE Detection of Galactic OVI Emission in the Halo above the Perseus Arm

Background observations obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE) toward l=95.4, b=36.1 show OVI 1032,1038 in emission. This sight line probes a region of stronger-than-average soft X-ray emission in the direction of high-velocity cloud Complex C above a part of the disk where Halpha filaments rise into the halo. The OVI intensities, 1600+/-300 ph/s/cm^2/sr (1032A) and 800+/-300 ph/s/cm^2/sr (1038A), are the lowest detected in emission in the Milky Way to date. A second sight line nearby (l=99.3, b=43.3) also shows OVI 1032 emission, but with too low a signal-to-noise ratio to obtain reliable measurements. The measured intensities, velocities, and FWHMs of the OVI doublet and the CII* line at 1037A are consistent with a model in which the observed emission is produced in the Galactic halo by hot gas ejected by supernovae in the Perseus arm. An association of the observed gas with Complex C appears unlikely.Comment: accepted for publication in ApJL, 11 pages including 3 figure

Intelligent System Development Using a Rough Sets Methodology

The purpose of this research was to examine the potential of the rough sets technique for developing intelligent models of complex systems from limited information. Rough sets a simple but promising technology to extract easily understood rules from data. The rough set methodology has been shown to perform well when used with a large set of exemplars, but its performance with sparse data sets is less certain. The difficulty is that rules will be developed based on just a few examples, each of which might have a large amount of noise associated with them. The question then becomes, what is the probability of a useful rule being developed from such limited information? One nice feature of rough sets is that in unusual situations, the technique can give an answer of 'I don't know'. That is, if a case arises that is different from the cases the rough set rules were developed on, the methodology can recognize this and alert human operators of it. It can also be trained to do this when the desired action is unknown because conflicting examples apply to the same set of inputs. This summer's project was to look at combining rough set theory with statistical theory to develop confidence limits in rules developed by rough sets. Often it is important not to make a certain type of mistake (e.g., false positives or false negatives), so the rules must be biased toward preventing a catastrophic error, rather than giving the most likely course of action. A method to determine the best course of action in the light of such constraints was examined. The resulting technique was tested with files containing electrical power line 'signatures' from the space shuttle and with decompression sickness data